The geographical division between the two clades has so far been in Cameroon, the only country where both virus clades have been found. The Congo Basin clade has historically caused more severe disease and was thought to be more transmissible. There are two distinct genetic clades of the monkeypox virus: the central African (Congo Basin) clade and the west African clade. Monkeypox virus is an enveloped double-stranded DNA virus that belongs to the Orthopoxvirus genus of the Poxviridae family. Animal hosts include a range of rodents and non-human primates. Monkeypox primarily occurs in central and west Africa, often in proximity to tropical rainforests, and has been increasingly appearing in urban areas. With the eradication of smallpox in 1980 and subsequent cessation of smallpox vaccination, monkeypox has emerged as the most important orthopoxvirus for public health. Monkeypox is a viral zoonosis (a virus transmitted to humans from animals) with symptoms similar to those seen in the past in smallpox patients, although it is clinically less severe.
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